C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2729403
The present invention relates to anti-CDH3 antibodies, which can be labeled with a radioisotope. Moreover, the present invention provides methods and pharmaceutical compositions that comprise an anti-CDH3 antibody as an active ingredient. Since CDH3 is strongly expressed in pancreatic, lung, colon, prostate, breast, gastric or liver cancer cells, the present inven-tion is useful in pancreatic, lung, colon, prostate, breast, gastric or liver cancer therapies.
La présente invention porte sur des anticorps anti-CDH3, qui peuvent être marqués par un radioisotope. De plus, la présente invention porte sur des procédés et des compositions pharmaceutiques qui comprennent en tant que principe actif un anticorps anti-CDH3. Etant donné que le CDH3 est fortement exprimé dans les cellules du cancer du pancréas, du poumon, du côlon, de la prostate, du sein, de l'estomac ou du foie, la présente invention est utile dans les thérapies des cancers du pancréas, du poumon, du côlon, de la prostate, du sein, de l'estomac ou du foie.
Endo Keigo
Katsu Masakazu
Nakamura Yusuke
Ng Pohsing
Shiba Yasuhiro
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Oncotherapy Science Inc.
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