C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/14 (2006.01) C07K 14/765 (2006.01) C07K 16/18 (2006.01) C07K 16/20 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2436426
A monoclonal antibody having a high specificity to ciguatoxins causative of ciguatera poisoning is provided. This monoclonal antibody is constructed by synthesizing a hapten comprising the IJKLM ring moiety of ciguatoxin, then preparing a protein conjugate by bonding a protein (KLH, BSA, etc.) to the hapten and using this synthetic hapten conjugate as an artificial antigen. This monoclonal antibody shows a specific reactivity with ciguatoxins but little reactivity with other marine polyether toxins such as okadaic acid.
La présente invention concerne un anticorps monoclonal présentant une spécificité élevée envers les ciguatoxines responsables des empoisonnements à la ciguatera. Pour obtenir l'anticorps monoclonal de l'invention, on synthétise un haptène comprenant le fragment cyclique IJKLM de la ciguatoxine, on prépare un conjugué de protéine en liant une protéine (KLH, BSA, etc.) à l'haptène, et on utilise le conjugué d'haptène synthétique comme antigène artificiel. L'anticorps monoclonal précité possède une réactivité spécifique envers les ciguatoxines, mais une faible réactivité envers les autres toxines polyéther marines telles que l'acide okadaïque.
Fujii Ikuo
Hirama Masahiro
Oguri Hiroki
Tsumuraya Takeshi
Japan Science And Technology Agency
Japan Science And Technology Corporation
Marks & Clerk
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