C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/44 (2006.01) C07K 16/46 (2006.01) C12N 9/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2258496
Disclosed are catalytic antibodies and polypeptides capable of degrading cocaine. Said catalytic antibodies and polypeptides are characterized by the amino acid sequence of their complementarity determining regions and framework regions. The present invention also discloses a pharmaceutical composition and a method for decreasing the concentration of cocaine in a subject. Finally, the invention discloses pharmaceutical compositions and methods for treating cocaine overdose and addiction in subjects.
L'invention concerne des anticorps catalytiques et des polypeptides capables de dégrader la cocaïne. Lesdits anticorps catalytiques et polypeptides sont caractérisés par la séquence d'acides aminés de leurs régions et régions d'infrastructure déterminantes de la complémentarité. La présente invention concerne également une composition pharmaceutique ainsi qu'un procédé pour réduire la concentration de cocaïne chez un sujet. Enfin, l'invention concerne des compositions et procédés pharmaceutiques pour traiter l'overdose de cocaïne et la cocaïnomanie chez les sujets.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Trustees Of Columbia University In The City Of New York
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