C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 38/46 (2006.01) A61P 25/36 (2006.01) C12N 9/16 (2006.01) C12N 9/18 (2006.01)
Patent
CA 2657246
Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.
Les modes de réalisation de l'invention divulgués concernent généralement des traitements anti-cocaïne. Spécifiquement, certains modes de réalisation de l'invention concernent des mutants d'estérase de cocaïne longue durée, efficaces et thermostables (CocE), qui peuvent protéger contre les effets toxiques et renforçants de la cocaïne chez les sujets. Les polypeptides CoCE mutants qui sont décris affichent une activité d'estérase thermostable. L'invention concerne également des procédés de traitement des conditions induites par la cocaïne chez un sujet en ayant besoin, par administration de CoCE mutant, ainsi que des procédés pour une analyse à rendement élevé de polypeptides d'estérase candidats.
Deng Shi-Xian
Gao Daquan
Ko Mei-Chuan Holden
Kwon Young Min
Landry Donald
Kirby Eades Gale Baker
The Regents Of The University Of Michigan
The Trustees Of Columbia University In The City Of New York
University Of Kentucky Research Foundation
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