Anti-cocaine vaccine

Details Anti-cocaine vaccine Anti-cocaine vaccine

C - Chemistry, Metallurgy

07

D

C07D 451/06 (2006.01) A61K 31/46 (2006.01) A61K 31/675 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07D 451/04 (2006.01) C07D 451/12 (2006.01) C07F 9/6561 (2006.01) C07K 16/06 (2006.01) C07K 16/44 (2006.01)

Patent

CA 2239058

An anti-cocaine vaccine employs a cocaine hapten conjugated to a carrier protein. The anti-cocaine vaccine elicits an immune response which reduces the psychoactive effects of cocaine consumption by the production of anti-cocaine polyclonal antibodies. The antibodies may be employed in an ELISA test for assaying cocaine. The immune response elicited by the anti-cocaine vaccine produces antibody producing cells which may be isolated and cloned for producing anti-cocaine monoclonal antibodies.

Vaccin anti-cocaïne mettant en oeuvre un haptène de la cocaïne conjugué à une protéine porteuse. Le vaccin anti-cocaïne déclenche une réponse immunitaire qui réduit les effets psychotropes dus à la consommation de cocaïne grâce à la production d'anticorps polyclonaux anti-cocaïne. Les anticorps peuvent être utilisés dans un essai ELISA en vue de doser la cocaïne. La réponse immunitaire déclenchée par le vaccin anti-cocaïne produit des cellules générant des anticorps qui peuvent être isolées et clonées en vue de produire des anticorps monoclonaux anti-cocaïne.

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