Anti-connexin compounds and uses thereof

Details Anti-connexin compounds and uses thereof Anti-connexin compounds and uses thereof

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/7115 (2006.01) A61K 31/712 (2006.01) A61K 31/7125 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) A61P 39/00 (2006.01)

Patent

CA 2596412

Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and for other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable.

La présente invention concerne des procédés et compositions permettant de moduler les activités des connexines. Cela s'adresse à des traitements portant sur des affections cardiovasculaires, vasculaires, neurologiques, et des lésions. Ces composés et procédés conviennent thérapeutiquement pour réduire la gravité des effets indésirables associés aux affections et troubles demandant une interruption localisée de la communication intercellulaire ou la prévention de l'ouverture à demi-canal.

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