Anti-ctla-4 antibody and cpg-motif-containing synthetic...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 31/7088 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2614320

The invention relates to administration of an anti-CTLA-4 antibody, particularly human antibodies to human CTLA-4, such as those having amino acid sequences of antibodies 3.1.1, 4.1.1, 4.8.1, 4.10.2, 4.13.1, 4.14.3, 6.1.1, 11.2.1, 11.6.1, 11.7.1, 12.3.1.1, 12.9.1.1, and MDX-010, in combination with an immunostimulatory nucleotide, i.e, CpG ODN PF3512676, for treatment of cancer. The invention relates to administering a combination of an anti-CTLA-4 antibody and CpG ODN PF3512676 as neoadjuvant, adjuvant, first-line, second- line, and third-line therapy of cancer, whether localized or metastasized, and at any point(s) along the disease continuum (e.g, at any stage of the cancer).

Cette invention concerne l'administration d'un anticorps anti-CTLA-4, en particulier l'administration d'anticorps humains dirigés contre le CTLA-4 humain, tels que ceux présentant des séquences aminoacides d'anticorps 3.1.1, 4.1.1, 4.8.1, 4.10.2, 4.13.1, 4.14.3, 6.1.1, 11.2.1, 11.6.1, 11.7.1, 12.3.1.1, 12.9.1.1 et MDX-010, en association avec un nucléotide immunostimulateur, le CpG ODN PF3512676, pour le traitement du cancer. L'invention concerne l'administration combinée d'un anticorps anti-CTLA-4 et du CpG ODN PF3512676, comme traitement néoadjuvant, adjuvant, de première intention, de deuxième intention ou de troisième intention contre le cancer localisé ou métastasé et cela, à n'importe quel stade de l'évolution de la maladie (c'est-à-dire à n'importe quel stade du cancer).

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