C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 31/7088 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2614320
The invention relates to administration of an anti-CTLA-4 antibody, particularly human antibodies to human CTLA-4, such as those having amino acid sequences of antibodies 3.1.1, 4.1.1, 4.8.1, 4.10.2, 4.13.1, 4.14.3, 6.1.1, 11.2.1, 11.6.1, 11.7.1, 12.3.1.1, 12.9.1.1, and MDX-010, in combination with an immunostimulatory nucleotide, i.e, CpG ODN PF3512676, for treatment of cancer. The invention relates to administering a combination of an anti-CTLA-4 antibody and CpG ODN PF3512676 as neoadjuvant, adjuvant, first-line, second- line, and third-line therapy of cancer, whether localized or metastasized, and at any point(s) along the disease continuum (e.g, at any stage of the cancer).
Cette invention concerne l'administration d'un anticorps anti-CTLA-4, en particulier l'administration d'anticorps humains dirigés contre le CTLA-4 humain, tels que ceux présentant des séquences aminoacides d'anticorps 3.1.1, 4.1.1, 4.8.1, 4.10.2, 4.13.1, 4.14.3, 6.1.1, 11.2.1, 11.6.1, 11.7.1, 12.3.1.1, 12.9.1.1 et MDX-010, en association avec un nucléotide immunostimulateur, le CpG ODN PF3512676, pour le traitement du cancer. L'invention concerne l'administration combinée d'un anticorps anti-CTLA-4 et du CpG ODN PF3512676, comme traitement néoadjuvant, adjuvant, de première intention, de deuxième intention ou de troisième intention contre le cancer localisé ou métastasé et cela, à n'importe quel stade de l'évolution de la maladie (c'est-à-dire à n'importe quel stade du cancer).
Gomez-Navarro Jesus
Hanson Douglas C.
Jungnelius Jarl Ulf Birger
Krieg Arthur M.
Readett David Robert John
Coley Pharmaceutical Group Inc.
Pfizer Inc.
Smart & Biggar
LandOfFree
Anti-ctla-4 antibody and cpg-motif-containing synthetic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-ctla-4 antibody and cpg-motif-containing synthetic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-ctla-4 antibody and cpg-motif-containing synthetic... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1747934