Anti-diabetic agents

Details Anti-diabetic agents Anti-diabetic agents

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) C07D 209/00 (2006.01) C07D 209/42 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2503727

The present invention provides compounds of formula (I), the prodrugs thereof, and the pharmaceutically acceptable salts of the compounds and prodrugs, wherein R', R'', R''', and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof in treating diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis, and tissue ischemia.

La présente invention a trait à des composés de formule (I), dans laquelle : R', R'', R''', et Z sont tels que définis dans la description .L'invention a également trait à leurs prodrogues, et les sels pharmaceutiquement acceptables des composés, des compositions pharmaceutiques comprenant lesdits composés, et leurs utilisations dans le traitement du diabète, de la résistance à l'insuline, de la neuropathie diabétique, de la néphropathie diabétique, de la rétinopathie diabétique, des cataractes, de l'hyperglycémie, de l'hypercholestérolémie, de l'hypertension, de l'hyperinsulinémie, de l'hyperlipémie, de l'athérosclérose, et de l'ischémie tissulaire.

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