A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 35/74 (2006.01)
Patent
CA 2044808
Abstract of the disclosure An anti-diabetic composition comprising an effective amount of at least one member of LPS whose microphage activation ED50 is 0.4 - 100 ng/ml of culture solution in terms of its limulus test-positive LPS content observed on a sigmoid curve prepared by determining the ability of the LPS to activate the TNF productivity of macrophage cultured in vitro, and plotting the macrophage activation ability (%) along the axis of ordinate wherein the ability is estimated to be O % in the case where it corresponds to the quantity of TNF produced by macrophage with no LPS added thereto. and 100 X is assigned to the macrophage activation ability which provides the maximal and constant quantity of TNF produced by the microphage and plotting the limulus test-positive LPS content of the LPS along the axis of abscissa on a logarithmic scale, in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, diabetes mellitus of said animal is prevented or cured: and a method of treating diabetes mellitus of an animal comprising administration to said animal an amount of the above composition effective to prevent or cure the diabetes mellitus of said animal.
Mizuno Den'ichi
Oshima Haruyuki
Soma Gen-Ichiro
Tsukioka Daisuke
Yoshimura Kiyoshi
Chiba Flour Milling Co. Ltd.
Mizuno Den'ichi
Smart & Biggar
Soma Gen-Ichiro
LandOfFree
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