Anti-diabetic agents and veterinary anti-diabetic agents

A - Human Necessities – 61 – K

Patent

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A61K 31/70 (2006.01) A61K 35/74 (2006.01)

Patent

CA 2044808

Abstract of the disclosure An anti-diabetic composition comprising an effective amount of at least one member of LPS whose microphage activation ED50 is 0.4 - 100 ng/ml of culture solution in terms of its limulus test-positive LPS content observed on a sigmoid curve prepared by determining the ability of the LPS to activate the TNF productivity of macrophage cultured in vitro, and plotting the macrophage activation ability (%) along the axis of ordinate wherein the ability is estimated to be O % in the case where it corresponds to the quantity of TNF produced by macrophage with no LPS added thereto. and 100 X is assigned to the macrophage activation ability which provides the maximal and constant quantity of TNF produced by the microphage and plotting the limulus test-positive LPS content of the LPS along the axis of abscissa on a logarithmic scale, in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, diabetes mellitus of said animal is prevented or cured: and a method of treating diabetes mellitus of an animal comprising administration to said animal an amount of the above composition effective to prevent or cure the diabetes mellitus of said animal.

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