Anti-drug antibody assay

Details Anti-drug antibody assay Anti-drug antibody assay

C - Chemistry, Metallurgy

07

K

C07K 16/42 (2006.01) C12N 5/16 (2006.01) G01N 33/564 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2662416

The invention provides an antibody binding specifically to Cynomolgus IgG characterized by not binding to Human IgG, and a method for the immunological determination of an immune complex (DA/ADA complex) of a drug antibody (DA) and an antibody against said drug antibody (anti-drug antibody, ADA) in a sample of a monkey species using a double antigen bridging immunoassay.

Anticorps se liant spécifiquement à Cynomolgus IgG, mais ne se liant pas l'IgG humaine, et procédé de détermination immunologique de complexe immune (complexe DA/ADA) anticorps de médicament (DA) et anticorps contre cet anticorps de médicament (ADA) dans un échantillon de l'espèce du singe, par le biais d'un immunoessai de pont antigénique double.

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