G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/543 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2644529
The invention provides a method for the immunological determination of an antibody against a drug antibody in a sample using a double antigen bridging immunoassay comprising a capture drug antibody and a tracer drug antibody, characterized in that the capture drug antibody is a mixture of said drug antibody conjugated to the solid phase at at least two different antibody sites and the tracer drug antibody is a mixture of said drug antibody conjugated to the detectable label at at least two different antibody sites.
L'invention concerne une méthode pour la détermination immunologique d'un anticorps dirigé contre un anticorps médicament dans un échantillon au moyen d'un dosage immunologique à double liaison d'antigène qui fait intervenir un anticorps médicament de capture et un anticorps médicament marqueur. La méthode de l'invention est caractérisée en ce que l'anticorps médicament de capture est un mélange dudit anticorps médicament conjugué à la phase solide d'au moins deux sites d'anticorps différents, et en ce que l'anticorps médicament marqueur est un mélange dudit anticorps médicament conjugué à la marque détectable au niveau des deux sites d'anticorps différents.
Hoesel Wolfgang
Stubenrauch Kay-Gunnar
Vogel Rudolf
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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