Anti-egfr antibody therapy based on an increased copy number...

Details Anti-egfr antibody therapy based on an increased copy number... Anti-egfr antibody therapy based on an increased copy number...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2604300

The invention relates to an individualized and personalized diagnosis and therapy of cancer based on specific molecular alterations which occur in specific tumor tissue of specific tumor patient populations. The therapy and diagnostic is based on the findings that proliferation and tumor growth of specific EGFR bearing tumor tissue expressing an amplified EGFR gene copy number may be abolished by anti-EGFR antibodies, while other individual molecular alterations such as mutations occurring in tumor tissues are unaffected by the same anti-EGFR antibody treatment.

La présente invention a trait à un diagnostic individualisé et personnalisé et une thérapie du cancer basés sur des altérations moléculaires spécifiques qui se produisent dans un tissu tumoral spécifique de populations de patients à tumeurs spécifiques. La thérapie et le diagnostic sont basés sur les observations que la prolifération et la croissance tumorale de tissu tumoral spécifique portant le EGFR exprimant une nombre amplifié de copies du gène EGFR peuvent être supprimées par des anticorps anti-EGFR, alors que d'autres altérations moléculaires individuelles telles que des mutations se produisant dans des tissus tumoraux ne sont pas affectés par le même traitement par anticorps anti-EGFR.

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