Anti-endotoxin compounds and related molecules and methods

Details Anti-endotoxin compounds and related molecules and methods Anti-endotoxin compounds and related molecules and methods

C - Chemistry, Metallurgy

07

H

C07H 15/12 (2006.01) A61K 31/335 (2006.01) A61K 31/70 (2006.01) C07D 307/18 (2006.01) C07D 493/04 (2006.01) C07F 9/655 (2006.01) C07H 3/04 (2006.01) C07H 5/06 (2006.01) C07H 13/00 (2006.01) C07H 13/06 (2006.01) C07H 15/26 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2079971

ANTI-ENDOTOXIN COMPOUNDS AND RELATED MOLECULES AND METHODS Abstract of the Disclosure Disclosed are lipid A analogs useful for the treatment of septic shock and LPS-mediated activation of viral infection. The lipid A analogs described herein provide useful therapeutics for the treatment or prevention of any LPS-mediated disorder. Such disorders include without limitation: endotoxemia (or sepsis syndrome) resulting from a Gram bacteremia (with its accompanying symptoms of fever, generalized inflammation, disseminated intravascular coagulation, hypotension, acute renal fail- ure, acute respiratory distress syndrome, hepatocellular destruction, and/or cardiac failure); and LPS-mediated exacerbation of latent or active viral infections (e.g., infection with HIV-1, cytomegaloviruses, herpes simplex viruses, and influenza virus). The lipid A analog is typi- cally administered in a pharmaceutically-acceptable formu- lation, e.g., dissolved in physiological saline or physio- logical saline which may include 5% glucose (for the purpose of increased analog solubility). Adminstration is by any appropriate route, but, ordinarily, it will be administered intravenously, either by intravenous injection or transfusion. When the lipid A analog is provided for the treatment of a viral infection, it may be administered in conjunction with appropriate viricidal agents. The lipid A analogs may be stored as a freeze-dried formula- tion.

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