C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/46 (2006.01) C12N 5/16 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2698146
It is intended to provide an antibody having an inhibitory activity against cell malignant transformation and/or tumor cell growth, etc. Solution The present invention provides an antibody which recognizes an epitope recognized by an antibody produced by a hybridoma SH348-1 (FERM BP-10836) or a hybridoma SH357-1 (FERM BP-10837), an antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, an antibody obtained by humanizing the antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, a pharmaceutical agent comprising the antibody as an active ingredient, etc.
La présente invention concerne un anticorps capable d'inhibition de la cancérisation d'une cellule et/ou la prolifération d'une cellule tumorale, et analogues. De manière spécifique, la présente invention concerne un anticorps pouvant reconnaître un épitope qui peut être reconnu par un anticorps produit par un hybridome SH 348-1 (FERM BP-10836) ou un hybridome SH 357-1 (FERM BP-10837); un anticorps produit par un hybridome SH 348-1 ou un hybridome SH 357-1; un anticorps produit par humanisation d'une anticorps produit par un hybridome SH 348-1 ou un hybridome SH 357-1; un agent pharmaceutique comportant un desdits anticorps en tant que principe actif, et analogues.
Agatsuma Toshinori
Hasegawa Jun
Nakahara Kaori
Ohtsuka Toshiaki
Takizawa Takeshi
Daiichi Sankyo Company Limited
Marks & Clerk
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