Anti-epileptics

Details Anti-epileptics Anti-epileptics

C - Chemistry, Metallurgy

07

F

C07F 9/30 (2006.01) A61K 31/66 (2006.01) C07F 9/58 (2006.01) C07F 9/655 (2006.01) C07F 9/6553 (2006.01)

Patent

CA 2045077

Compounds having GABA B-antagonistic properties, for example those of formula I see Formula I wherein one of the radicals R1, R2 and R3 is hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radical, another is hydrogen or, in the case of R1 or R2, hydroxy or, in the case of R1, halogen or, in the case of R2 together with R2', oxo, and the remaining radical is hydrogen, R1' is hydrogen or halogen, R2' is hydrogen, hydroxy or, together with R2, is oxo, R4 and R5 are hydrogen or R4 is an araliphatic or heteroarylaliphatic radical and R5 is hydrogen or an aliphatic radical, and R is an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, araliphatic, heteroarylaliphatic or aromatic radical having at least 2 carbon atoms or, when R1 is hydrogen or hydroxy, R2 is an aromatic radical and R1', R2' and R3 are hydrogen, R is methyl, and their pharmaceutically acceptable salts, can be used as active ingredients in medicaments for the treatment of epilepsies of the "petit mal" type. The invention relates also to novel compounds of formula I and processes for the preparation thereof.

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