Anti-ergotypic t cells for the treatment or prevention of...

Details Anti-ergotypic t cells for the treatment or prevention of... Anti-ergotypic t cells for the treatment or prevention of...

C - Chemistry, Metallurgy

07

K

167/104, 530/15.

C07K 14/435 (2006.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2032138

2032138 9014068 PCTABS00002 Autoimmune diseases can be treated by administering T cells which are specific to a T cell receptor which is present on activated T cells but which is not present on non-activated T cells and which T cells are non-specific for the T cell receptor which is specific for the target protein of the autoimmune disease being treated. Such a T cell receptor is referred to as an ergotope as it is a marker of activation. Autoimmune diseases can also be treated by administering ergotypic T cells, fragments or proteins which include or comprise an ergotope. Such ergotypic T cells, fragments and proteins will serve to raise T cells which are specific to an ergotope in vivo and will thus attack the natural ergotopes on the autoimmune T cells.

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