Anti-excitotoxic sustained release intraocular implants and...

Details Anti-excitotoxic sustained release intraocular implants and... Anti-excitotoxic sustained release intraocular implants and...

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 31/13 (2006.01)

Patent

CA 2565459

Biocompatible intraocular implants include an anti-excitotoxic agent and a polymer that is effective to facilitate release of the anti-excitotoxic agent into an eye for an extended period of time. The therapeutic agents like NMDA receptor anragonists like adamantine or memantine may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.

L'invention porte sur des implants intraoculaires biocompatibles qui comprennent un agent anti-excitotoxique et un polymère qui sert à faciliter la libération efficace de l'agent anti-excitotoxique dans un oeil pendant une période de temps prolongée. Les agents thérapeutiques, par exemple des antagonistes du récepteur NMDA tels que l'adamantine ou la mémantine, peuvent être associés à une matrice polymère biodégradable, par exemple une matrice sensiblement dépourvue d'alcool polyvinylique. Les implants de l'invention peuvent être placés dans un oeil pour traiter ou réduire la fréquence d'une ou plusieurs pathologies oculaires telles que la détérioration de la rétine, y compris le glaucome et la vitréorétinopathie proliférative.

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