Anti-factor xiia therapy

Details Anti-factor xiia therapy Anti-factor xiia therapy

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61P 7/02 (2006.01) C07K 16/36 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2649037

A method of preventing arterial thrombosis in a subject comprising administering to said subject a therapeutically effective amount of an antibody or epitope-binding fragment or derivative thereof, wherein said antibody, fragment or derivative specifically binds to activated Factor XIIa and prevents the interaction of activated Factor XIIa with its physiological substrates.

L'invention concerne une méthode destinée à prévenir la thrombose artérielle chez un sujet et consistant à administrer à ce sujet une dose thérapeutiquement efficace d'un anticorps ou d'un fragment de liaison à un épitope ou d'un dérivé correspondant, ledit anticorps, fragment ou dérivé se liant spécifiquement au facteur XIIa activé et empêchant une interaction du facteur XIIa activé avec ses substrats physiologiques.

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