Anti-fcrn antibodies for treatement of auto/allo immune...

Details Anti-fcrn antibodies for treatement of auto/allo immune... Anti-fcrn antibodies for treatement of auto/allo immune...

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/42 (2006.01)

Patent

CA 2637929

Antibodies to heavy chain of human FcRn are provided which function as non- competitive inhibitors of IgG binding to FcRn. The antibodies may be polyclonal, monoclonal, chimeric or humanized, or antigen binding fragments thereof. These antibodies are useful for reducing the concentration of pathogenic IgGs in individuals and therefore used as a therapeutic tool in autoimmune and alloimmune conditions.

Cette invention concerne des anticorps dirigés contre la chaîne lourde du récepteur FcRn humain qui jouent le rôle d'inhibiteurs non compétitifs de la liaison de l'immunoglobuline G (IgG) au récepteur FcRn. Les anticorps peuvent être polyclonaux, monoclonaux, chimériques ou humanisés ou des fragments de liaison à l'antigène de ceux-ci. Ces anticorps peuvent servir à réduire la concentration d'immunoglobulines G pathogènes chez des individus et sont par conséquent utilisés comme outil thérapeutique contre des états auto-immuns et allo-immuns.

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