A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/20 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01)
Patent
CA 2534973
Antibodies to FcRn are provided which are non-competitive inhibitors of IgG binding to FcRn. The antibodies may be polyclonal or monoclonal or antigen binding fragment thereof. These antibodies are useful for reducing the concentration of pathogenic IgGs in individuals and therefore used as a therapeutic tool in autoimmune and alloinimune conditions.
L'invention concerne des anti-corps anti-FcRn qui constituent des inhibiteurs non compétitifs d'une liaison d'IgG à FcRn. Lesdits anti-corps peuvent constituer un fragment associé de liaison polyclonal ou monoclonal ou d'antigène. Ces anti-corps sont utilisés pour diminuer la concentration d'IgG pathogènes chez des individus et sont donc utilisés comme agents thérapeutiques dans des troubles auto-immuns et allo-immuns.
Balthasar Joseph P.
Hansen Ryan J.
Jin Feng
Mccarthy Tetrault Llp
The Research Foundation Of State University Of New York
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