Anti-ferroportin 1 monoclonal antibodies and uses thereof

Details Anti-ferroportin 1 monoclonal antibodies and uses thereof Anti-ferroportin 1 monoclonal antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 7/06 (2006.01) C12N 15/13 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2745618

Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.

L'invention porte sur des anticorps monoclonaux et des fragments de liaison à un antigène de ceux-ci qui se lient à, et inhibent l'activité de FPN1 humaine, et qui sont efficaces pour maintenir ou augmenter le transport de fer hors de cellules de mammifère et/ou maintenir ou augmenter le niveau de fer sérique, le comptage de réticulocytes, le comptage de globules rouges, l'hémoglobine, et/ou l'hématocrite dans un sujet in vivo.

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