A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61K 31/517 (2006.01)
Patent
CA 2113229
The invention provides an anti-fibrotic composition, comprising an amount of a compound of formula I: (see fig.1) or a physiologically acceptable salt thereof, wherein: n = 1 to 3; R1 is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy; R2 is a member of the group consisting of hydroxy, acetoxy, and lower alkoxy; and R3 is a member of the group consisting of hydrogen and lower alkenoxy-carbonyl; effective to inhibit collagen type I synthesis as active ingredient therein.
L'invention porte sur une composition anti-fibreuse, renfermant une certaine quantité d'un composé de formule I (voir fig. 1), ou un sel physiologiquement acceptable de ce composé, où : n = 1 à 3; R1 est choisi parmi un groupe hydrogène, halogène, nitro, benzo, alkyle inférieur, phényle ou alcoxy inférieur; R2 est choisi parmi un groupe hydroxy, acétoxy ou alcoxy inférieur; enfin R3 est choisi parmi un groupe hydrogène ou alcénoxy(inférieur)carbonyle. La composition renfermant ce type de composé comme ingrédient actif est un inhibiteur efficace de la synthèse de collagène de type I.
Nagler Arnon
Pines Mark
Slavin Shimon
Agricultural Research Organization Ministry Of Agriculture
Hadasit Medical Research Services & Development Company Ltd.
Riches Mckenzie & Herbert Llp
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