Anti-flt3 antibodies

Details Anti-flt3 antibodies Anti-flt3 antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2726522

The present invention provides fully human antibodies that specifically bind to human FLT3 within extracellular domains 4 or 5 with high affinity. The invention further provides methods of treating leukemia by administering an effective amount of an antibody either alone or in combination with an anti-cancer agent or treatment including methotrexate.

Linvention concerne des anticorps entièrement humains se liant spécifiquement au FLT3 humain dans les domaines extracellulaires 4 ou 5 avec une affinité élevée. Linvention concerne également des méthodes de traitement de la leucémie consistant à administrer une quantité efficace dun anticorps, seul ou associé à un agent ou traitement anticancéreux contenant du méthotrexate.

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