Anti-fn14 antibodies and uses thereof

Details Anti-fn14 antibodies and uses thereof Anti-fn14 antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01) C12N 5/02 (2006.01) C12N 5/16 (2006.01)

Patent

CA 2723973

Antibodies and antibody fragments that bind to the receptor Fn14 and induce or enhance cell killing of Fn14-expressing cancer cells are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to induce death of a tumor cell and treat disorders and in a subject.

L'invention concerne des anticorps et des fragments d'anticorps qui se lient au récepteur Fn14 et qui induisent ou augmentent la destruction cellulaire de cellules cancéreuses exprimant Fn14. L'invention concerne des procédés d'utilisation de ces anticorps et fragments d'anticorps pour induire la mort cellulaire d'une cellule tumorale et pour traiter des troubles chez un sujet.

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