C - Chemistry – Metallurgy – 12 – M
Patent
C - Chemistry, Metallurgy
12
M
C12M 3/02 (2006.01) B01D 19/02 (2006.01) C12M 1/21 (2006.01)
Patent
CA 2161765
An anti-foam device for a bioreactor (1, 2) is provided consisting of a perforated plate (8), made by hydrophobic material, which rotates at the surface (4) of the liquid culture medium (3) contained in the bioreactor vessel (1), said perforated plate (8) being perpendicular to (or having an inclination from 45° to 90° in respect of) the surface (4) of said culture medium (3) and partially immersed into said culture medium (3). On a preferred embodiment, said perforated plate (8), made of a silicone polymer, is held by a metal support (11); if a spinfilter (15) is provided in said bioreactor (1, 2), said perforated plate (8) is divided in two separate equal sections (12) which are held by two metal supports (11) linked to said spinfilter (15) on the opposite sides thereof. Finally, said anti-foam device allows a significant improvement of the surface aeration rate of the liquid culture medium (3) by increasing the gas exchange rate at the gas/liquid interface (4).
Un dispositif anti-mousse pour bioréacteur (1, 2) est constitué d'une plaque perforée (8) faite dans un matériau hydrophobe et qui tourne au niveau de la surface (4) du milieu de culture liquide (3) contenu dans la cuve (1) du bioréacteur, cette plaque perforée (8) étant perpendiculaire à la surface (4) du milieu de culture (3) (ou ayant une inclinaison de 45 DEG à 90 DEG par rapport à celle-ci), et étant partiellement immergée dans ce milieu de culture (3). Selon un mode préféré de réalisation, cette plaque perforée (8), en polymère de silicone, est maintenue par un support métallique (11); si on place un filtre rotatif (15) dans ce bioréacteur (1, 2), la plaque perforée (8) est alors divisée en deux sections égales, séparées (12) qui sont maintenues par deux supports métalliques (11) reliés au filtre rotatif (15) sur les côtés opposés de celui-ci. Enfin, ce dispositif anti-mousse améliore de manière significative le taux d'aération de la surface du milieu de culture liquide (3) grâce à l'augmentation du taux d'échange gazeux intervenant à l'interface gaz/liquide (4).
Mignot Gerard
Rodicio Ignacio
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
Laboratoires Serono S.a.
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