C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/61 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/90 (2006.01) C12Q 1/02 (2006.01) C12Q 1/533 (2006.01)
Patent
CA 2223484
Substantially pure C. albicans topoisomerase I protein is disclosed. Nucleic acid molecules that encode C. albicans topoisomerase I protein, recombinant expression vectors that comprise a nucleic acid sequence that encodes C. albicans topoisomerase I protein, and host cells that comprise recombinant expression vectors that comprise nucleic acid sequences that encode C. albicans topoisomerase I protein are disclosed. Fragments of nucleic acid molecules with sequences encoding C. albicans topoisomerase I protein and oligonucleotide molecules that comprise a nucleotide sequence complementary to fragment of a nucleotide sequence that encodes C. albicans topoisomerase I protein are disclosed. Antibodies which bind to an epitope on C. albicans topoisomerase I protein are disclosed. Methods of identifying inhibitors of C. albicans topoisomerase I protein are disclosed. Camptothecin analogs useful as inhibitors of C. albicans topoisomerase I protein are disclosed and methods of using camptothecin analogs as inhibitors of C. albicans topoisomerase I protein are disclosed.
L'invention concerne la protéine topoisomérase I de C. albicans sensiblement pure, des molécules d'acide nucléique codant la protéine topoisomérase I de C. albicans, des vecteurs d'expression obtenus par recombinaison, comprenant une séquence d'acide nucléique codant la protéine topoisomérase I de C. albicans et des cellules hôtes qui renferment des vecteurs d'expression obtenus par recombinaison contenant les séquences d'acides nucléiques codant la protéine topoisomérase I de C. albicans, des fragments de molécules d'acide nucléique comprenant des séquences codant la protéine topoisomérase I de C. albicans, des molécules oligonucléotidiques comprenant une séquence nucléotidique complémentaire du fragment d'une séquence nucléotidique codant la protéine topoisomérase I de C. albicans, des anticorps qui se fixent sur un épitope de la protéine topoisomérase I de $I(C.) albicans, des procédés pour identifier des inhibiteurs de la protéine topoisomérase I de C. albicans, des analogues de la camptothécine utiles comme inhibiteurs de la protéine topoisomérase I de C. albicans, ainsi que des méthodes d'utilisation des analogues de la camptothécine comme inhibiteurs de la protéine topoisomérase I de C. albicans.
Cole Strauss Allyson
Gerhold David L.
Kmiec Eric B.
Borden Ladner Gervais Llp
Thomas Jefferson University
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