C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61L 2/16 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2200069
The present invention relates generally to anti-fungal peptides derived from or based on Domain III (amino acids 142-169) of bactericidal/permeability- increasing protein (BPI) and therapeutic uses of such peptides. The mentioned peptides all have from seven to twelve amino acids and comprise a core sequence of LIQL, IQLF, WLIQL, LIQLF and WLQLF and one or more basic amino acids in the terminal regions. Peptides are either linear or cyclic.
La présente invention se rapporte en général à des peptides antifongiques dérivés du Domaine III ou basés sur le Domaine III (acides aminés 142-169) de la protéine augmentant le pouvoir bactéricide et la perméabilité, et aux utilisations thérapeutiques de ces peptides. Les peptides mentionnés possèdent tous sept à douze acides aminés et comprennent une séquence de base (LIQL, IQLF, WLIQL, LIQLF et WLQLF) et au moins un acide aminé à caractère basique dans les régions terminales. Ces peptides sont soit linéaires, soit cycliques.
Fadem Mitchell B.
Lim Edward
Little Roger G. II
Mbm Intellectual Property Law Llp
Xoma Corporation
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