Anti-gfralpha3 antibodies

Details Anti-gfralpha3 antibodies Anti-gfralpha3 antibodies

A - Human Necessities

61

K

A61K 38/00 (2006.01) C07K 2/00 (2006.01) C07K 4/00 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2612417

Antibodies and antibody fragments that bind to the receptor GFRalpha3 and inhibit formation of a Neublastin-GFRalpha3-Ret ternary complex are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to inhibit phosphorylation of Ret in a cell and treat disorders and in a subject.

L'invention concerne des anticorps et des fragments d'anticorps se liant au récepteur GFRalpha3 et inhibant la formation d'un complexe ternaire Neublastin-GFRalpha3-Ret. L'invention concerne également des procédés d'utilisation des anticorps et des fragments d'anticorps aux fins d'inhibition de la phosphorylation de Ret dans une cellule et de traitement de troubles et chez un sujet.

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