Anti-glycated cd59 antibodies and uses thereof

Details Anti-glycated cd59 antibodies and uses thereof Anti-glycated cd59 antibodies and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 38/17 (2006.01) A61K 45/06 (2006.01) A61P 3/10 (2006.01) C07K 7/06 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/12 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2612303

The invention includes antibodies or antigen-binding fragments thereof which bind specifically to glycated CD59, compositions containing one or a combination of such antibodies or antigen-binding fragments thereof, hybridoma cell lines that produce the antibodies, and methods of producing and using the antibodies or antigen-binding fragments thereof for diagnosis and treatment of diabetic conditions and diabetic complications or diabetes-associated conditions. The invention also involves in some embodiments assays, diagnostics, kits, and assay components for determining levels of glycated CD59 in subjects. Treatments for subjects based upon levels of glycated CD59 also are provided.

L'invention concerne des anticorps ou des fragments de liaison d'antigènes de ceux-ci qui se lient spécifiquement à CD59 glycaté, des compositions contenant une ou plusieurs combinaison(s) de ces anticorps ou des fragment de liaison d'antigènes de ceux-ci, des lignées cellulaires d'hybridome qui produisent les anticorps, et des procédés de production et d'utilisation de ces anticorps ou des fragment de liaison d'antigènes de ceux-ci pour diagnostiquer et traiter les états diabétiques, les complications diabétiques ou les états associés au diabète. L'invention concerne également, dans certains modes de réalisation, des dosages, des diagnostics, des kits et des composants de dosage permettant de déterminer les niveaux de CD59 glycaté chez des sujets. L'invention concerne également des traitements destinés audits sujets basés sur ces niveaux de CD59 glycaté.

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