Anti-glypican 3 antibody

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 1/16 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2544692

It is intended to provide an antibody capable of binding to a specific region of glypican 3 and a humanized antibody constructed based on the above antibody. The anti-GPC3 antibody as described above, which has high ADCC and CDC activities compared with the existing antibodies, is useful as a cell proliferation inhibitor, an anticancer agent and a cancer diagnostic.

Anticorps capable de se lier à une région spécifique du glypican 3 et anticorps humanisé élaboré à partir de l'anti-corps ci-dessus. L'anticorps anti-GPC3 décrit ci-dessus, qui a des activités ADCC et CDC élevées comparées aux anticorps existants, est utile en tant qu'inhibiteur de prolifération de cellule, en tant qu'agent anticancéreux, et dans le diagnostic du cancer.

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