Anti-gpr-9-6 and anti-teck antibodies and methods of...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 5/20 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2365230

The invention relates to an antibody or antigen-binding fragment thereof which binds to the CC chemokine receptor GPR-9-6 and blocks the binding of a ligand (e.g, TECK) to the receptor. The invention also relates to a method of identifying agents (molecules, compounds) which can bind to GPR-9-6 and inhibit the binding of a ligand (e.g., TECK) and/or modulate a function of GPR- 9-6. The invention further relates to a method of modulating a function of GPR- 9-6, and to the use of the antibodies, antigen-binding fragments and agents identified by the method of the invention in research, therapeutic, prophylactic and diagnostic methods.

L'invention a trait à un anticorps ou à un fragment de celui-ci se liant à un antigène, qui se lie au récepteur GPR-9-6 de chémokine CC et bloque la liaison d'un ligand (p. ex. TECK) à ce récepteur. L'invention a également trait à un procédé d'identification d'agents (molécules, composés) susceptibles de se lier à GPR-9-6 et d'inhiber la liaison d'un ligand (p. ex. TECK) et/ou de moduler une fonction de GPR-9-6. L'invention a en outre trait à un procédé de modulation d'une fonction de GPR-9-6, et à l'utilisation des anticorps, des fragments se liant à un antigène et des agents identifiés à l'aide du procédé de l'invention dans des procédés de recherche, thérapeutiques, prophylactiques et diagnostiques.

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