Anti-gram-positive bacterial methods and materials

Details Anti-gram-positive bacterial methods and materials Anti-gram-positive bacterial methods and materials

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2181164

The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product alone has a bactericidal or growth inhibitory effect on selected gram-positive organisms. BPI protein product also increases the susceptibility of gram-positive organisms to antibiotics and can even reverse resistance of gram-positive organisms to antibiotic.

L'invention concerne des procédés de traitement d'infections bactériennes à Gram positif par administration d'un produit d'une protéine bactéricide et d'augmentation de perméabilité (BPI) seul ou combiné à un antibiotique. Le produit de protéine BPI seul produit un effet bactéricide ou inhibiteur de croissance sur des organismes sélectionnés à Gram positif. Le produit de protéine BPI augmente également la sensibilité d'organismes à Gram positif aux antibiotiques et peut même inverser la résistance d'organismes à Gram positif aux antibiotiques.

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