Anti-helicobacter ester and carbamate derivatives of azolones

Details Anti-helicobacter ester and carbamate derivatives of azolones Anti-helicobacter ester and carbamate derivatives of azolones

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 233/70 (2006.01) C07D 249/12 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2185552

The invention is concerned with the compounds having formula (I), the pharmaceutically acceptable acid addition salts and the stereochemically isomeric form thereof, wherein X and Y are CH or N; R1, R2 and R3 are hydrogen or C1-4 alkyl; R4 and R5 are hydrogen, halo, C1-4 alkyl, C1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R6 is C1-6 alkyl, hydroxy C1-6 alkyl, C1-4 alkyloxy C1-6 alkyl, phenyl or phenyl C1-4 alkyl; Z is C=O or CHOH; and (a) is a radical of formula (a-1), (a-2), (a-3), (a-4), (a-5), (a-6) or (a-7); compositions comprising said compounds, processes for preparing the same and the use of these compounds for treating Helicobacter related diseases.

L'invention concerne des composés de la formule (I), les sels d'addition d'acide, pharmacologiquement acceptables, ainsi que les formes stéréochimiquement isomères de ceux-ci. Dans cette formule, X et Y représentent CH ou N; R?1¿, R?2¿ et R?3¿ représentent hydrogène ou alcoyle C¿1-4?; R?4¿ et R?5¿ représentent hydrogène, halo, alcoyle C¿1-4?, alcoyloxy C¿1-4?, hydroxy, trifluorométhyle, trifluorométhyloxy ou difluorométhyloxy; R?6¿ représente alcoyle C¿1-6?, hydroxy alcoyle C¿1-6?, alcoyloxy C¿1-4? alcoyle C¿1-6?, phényle ou phényle alcoyle C¿1-4?; Z représente C=O ou CHOH; et (a) est un radical de formule (a-1), (a-2), (a-3), (a-4), (a-5), (a-6) ou (a-7). L'invention concerne des compositions comprenant ces composés, des procédés de préparation de ceux-ci ainsi que l'utilisation de ces composés dans le traitement de maladies associées à l'Helicobacter.

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