Anti-helicobacter pylori compositions containing...

A - Human Necessities – 61 – K

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Details

A61K 31/425 (2006.01) A61K 31/40 (2006.01) A61K 31/407 (2006.01) A61K 31/415 (2006.01) A61K 31/4188 (2006.01) A61K 31/427 (2006.01) C07D 477/04 (2006.01) C07D 477/20 (2006.01)

Patent

CA 2253860

1-Methylcarbapenem derivatives of general formula (I) and pharmacologically acceptable salts and esters thereof, useful as the active ingredient of anti- <u>Helicobacter pylori</u> compositions (such as therapeutic or preventive agents for <u>Helicobacter pilori</u>infections, particularly the therapeutic agents). In said formula, R1 is (IIa), (IIb), (IIc) or (IId), wherein R2 is hydrogen or alkyl; and R3 is hydrogen or alkyl.

Cette invention se rapporte à des dérivés de 1-méthylcarbapenem représentés par la formule générale (I) et à des sels et esters pharmaceutiquement acceptables de ces dérivés, qui s'avèrent utiles en tant qu'ingrédient actif des compositions de lutte contre <u>Helicobacter pylori</u> (notamment en tant qu'agents thérapeutiques ou préventifs des infections associées à <u>Helicobacter pylori</u>, et plus particulièrement en tant qu'agents thérapeutiques). Dans la formule (I), R?1¿ est représenté par l'une des formules (IIa), (IIb), (IIc) ou (IId) dans lesquelles R?2¿ est hydrogène ou alkyle et R?3¿ est hydrogène ou alkyle.

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