A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) C07D 215/60 (2006.01)
Patent
CA 2290549
Medicinal compositions against Helicobacter pylori, which contain as the active ingredient a 1-hydroxy-3-methyl-quinolone derivative represented by formula (I) or its pharmaceutically acceptable salt. Because of having an antibacterial effect on H. pylori, the above compound is useful in treating or preventing infection of human beings with H. pylori and infections of animals with bacteria belonging to the genus Helicobacter in relation thereto. The above compositions are useful in the prevention (including the prevention of recurrence) and treatment of peptic ulcers (gastric ulcer, duodenal ulcer, etc.), inflammations (acute or chronic gastritis or duodenitis), diseases in the upper part of the digestive tract (gastric cancer, etc.), mucosa-associated lymphoid tissue (MALT) lymphoma, chronic heart diseases, etc.
L'invention porte sur des compositions médicamenteuses contre l'Helicobacter pylori dont le principe actif est un dérivé de la 1-hydroxy-3-méthylquinolone représenté par la formule (I) suivante, ou ses sels pharmacocompatibles. En raison de son pouvoir antibactérien sur l'Helicobacter pylori, le composé ci-dessus peut traiter ou prévenir chez l'homme les infections dues à l'Helicobacter pylori, et chez l'animal, les infections par des bactéries du genre Helicobacter. Les compositions ci-dessus peuvent notamment être utilisées pour la prévention (y compris la prévention des récidives) et le traitement des ulcères gastroduodénaux (etc.), des inflammations (gastrites aiguës ou chroniques ou duodénites), des maladies des voies digestives supérieures (cancer gastrique, etc.), des lymphomes des tissus lymphoïdes associés aux muqueuses, des maladies cardiaques chroniques, etc.
Komiya Masayuki
Rantiatmodjo Ratna Murni
Tanaka Kouichi
Watanabe Masato
Astellas Pharma Inc.
Dennison Associates
P.t. Kalbe Farma
Yamanouchi Pharmaceutical Co. Ltd.
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