Anti-hepatitis b viral oligonucleotides

Details Anti-hepatitis b viral oligonucleotides Anti-hepatitis b viral oligonucleotides

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2178811

The invention relates to methods and compositions for inhibition of viral replication. In particular, complete and irreversible termination of replication of hepatitis B virus is achieved by introducing into a target cell an oligonucleotide complementary to HBV plus strand and 5' and 3' flanking nucleotides.

Méthodes et compositions inhibant la réplication virale. Il est, en particulier, possible d'obtenir l'arrêt total et irréversible de la réplication du virus de l'hépatite B (HBV) en introduisant dans une cellule cible un oligonucléotide complémentaire du brin DR2 plus du HBV et les nucléotides 5' et 3' adjacents.

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