Anti-hepcidin-25 selective antibodies and uses thereof

Details Anti-hepcidin-25 selective antibodies and uses thereof Anti-hepcidin-25 selective antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/26 (2006.01) A61K 39/395 (2006.01) A61P 7/06 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2733497

Monoclonal antibodies are provided that bind to the N--terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA.

L'invention porte sur des anticorps monoclonaux qui se lient à l'extrémité N-terminale de l'hepcidine-25 humaine et sont caractérisés comme ayant des affinité et sélectivité élevées pour le polypeptide. Les anticorps de l'invention sont utiles pour augmenter les taux de fer dans le sérum, la numération des réticulocytes, la numération des globules rouges, l'hémoglobine et/ou l'hématocrite dans un être humain et pour le traitement de divers troubles, tels que l'anémie, dans un sujet humain. Les anticorps de l'invention sont également utiles comme outils analytiques, par exemple dans un ELISA en sandwich.

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