Anti-hiv agent

Details Anti-hiv agent Anti-hiv agent

A - Human Necessities

61

K

A61K 31/66 (2006.01) A61K 31/045 (2006.01) A61K 31/105 (2006.01) A61K 31/22 (2006.01) A61K 31/23 (2006.01)

Patent

CA 2140352

ABSTRACT The invention is directed to an anti-HIV agent and a prophylactic and remedial preparation for AIDS, comprising, as an active ingredient, a disulfide represented by the general formula (1): R1-S-S-R2 (1) wherein R1 means an alkenyl group having 2-20 carbon atoms, and R2 denotes an alkenyl group having 2-20 carbon atoms or an alkyl group having 1-20 carbon atoms, or an unsaturated alcohol or an ester thereof represented by the general formula (2): R1-O-R3 (2) wherein R1 means an alkenyl group having 2-20 carbon atoms, and R3 denotes a hydrogen atom, an acyl group having 2-20 carbon atoms a phosphoric group or a phospholipid group. These compounds have a marked proliferation-inhibiting effect on cells persistently infected with HIV, on which the conventional anti-HIV agents have had no effect, and are useful for treatment for AIDS.

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