Anti-hiv composition, production method thereof and medicament

Details Anti-hiv composition, production method thereof and medicament Anti-hiv composition, production method thereof and medicament

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61P 31/18 (2006.01) A61K 31/727 (2006.01) A61K 31/737 (2006.01)

Patent

CA 2481325

The invention relates to an anti-HIV composition and to the production method thereof. The inventive composition comprises a polyanion and a molecule capable of inducing exposure of the CD4I epitope of the viral protein gp120. The polyanion can be selected, for example, from the group comprising heparin, heparan sulphate and a polyanion that is equivalent to heparin or heparan sulphate. The molecule capable of inducing exposure of the CD4I epitope of the viral protein gp120 is a CD4 peptide or a derivative of same. The invention also relates to the use of said composition for the production of a medicament, such as a medicament intended for the treatment of AIDS.

La présente invention se rapporte à une composition anti-VIH et à son procédé de fabrication. La composition de la présente invention comprend un polyanion et une molécule capable d'induire l'exposition de l'épitope CD4i de la protéine virale gp120. Le polyanion peut être choisi par exemple dans le groupe constitué de l'héparine, de l'héparane sulfate, et d'un polyanion équivalent à l'héparine ou à l'héparane sulfate. La molécule capable d'induire l'exposition de l'épitope CD4i de la protéine virale gp120 est un peptide CD4 ou un dérivé de celui-ci. La présente invention se rapporte également à l'utilisation de ladite composition pour la fabrication d'un médicament, notamment d'un médicament destiné au traitement du sida.

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