Anti-human .alpha.9 integrin antibody and use thereof

Details Anti-human .alpha.9 integrin antibody and use thereof Anti-human .alpha.9 integrin antibody and use thereof

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61P 19/08 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2753280

The present invention relates to an anti-human .alpha.9 integrin antibody. More particularly, the present invention relates to: a monoclonal antibody, a chimeric antibody, a humanized antibody and a human antibody that specifically recognize human .alpha.9 integrin; a hybridoma cell that produces the monoclonal antibody; a method for producing the monoclonal antibody; a method for producing the hybridoma cell; a therapeutic agent comprising the anti-human .alpha.9 integrin antibody; a diagnostic agent comprising the human .alpha.9 integrin antibody; and a method for screening for a compound that inhibits the activity of human .alpha.9 integrin.

L'invention porte sur : un anticorps dirigé contre l'intégrine a9 humaine, plus spécifiquement un anticorps monoclonal, un anticorps chimérique, un anticorps humanisé ou un anticorps humain, qui est apte à reconnaître l'intégrine a9 humaine de manière spécifique ; une cellule hybridome qui permet de produire l'anticorps monoclonal ; un procédé de production de l'anticorps monoclonal ; un procédé de production de la cellule hybridome ; un agent thérapeutique renfermant l'anticorps dirigé contre l'intégrine a9 humaine ; un agent de diagnostic renfermant l'anticorps dirigé contre l'intégrine a9 humaine ; un procédé pour la recherche par criblage d'un composé apte à inhiber l'activité de l'intégrine a9 humaine ; et autres.

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