A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/129
A61K 39/00 (2006.01) A61K 47/48 (2006.01) C07K 16/30 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1287578
Abstract of the Disclosure Immunotoxins comprising a cytotoxic moiety and an antigen binding portion selected from the group consisting of Fab, Fab' and F(ab')2 fragments of a monoclonal antibody, which binds to human ovarian cancer tissue, having one of the following capabilities are claimed: cytotoxic ID50 of about 10 nM or less against human ovarian cancer cells, retardation of human ovarian cancer tumor growth in mammals, or extension of survival of a mammal carrying a human ovarian cancer tumor. Antigens or epitopes to which the monoclonal antibodies bind are identified and characterize the immunotoxins. In a preferred embodiment an immunotoxin comprising at least an antigen binding portion of a monoclonal antibody, which binds to human transferrin receptor, but does not block binding of transferrin to the receptor, is described and claimed. Immunotoxin comprising the (F(ab')2 region of the antitransferrin monoclonal antibody are also claimed. Methods of killing human ovarian cancer cells, retarding the growth of human ovarian cancer tumors in mammals and extending the survival of mammals carrying human ovarian cancer tumors are claimed.
524645
Bjorn Michael J.
Frankel Arthur E.
Laird Walter J.
Ring David B.
Winkelhake Jeffrey L.
Borden Ladner Gervais Llp
Chiron Corporation
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