C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/16 (2006.01) C07K 14/75 (2006.01) C07K 16/36 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01) G01N 33/86 (2006.01) C12Q 1/56 (2006.01)
Patent
CA 2594289
A monoclonal antibody to soluble fibrin that is capable of specifically recognizing a structural change site newly occurring in the C-terminal region of A.alpha.-chain of soluble fibrin formed by thrombin digestion of fibrinogen; a hybridoma capable of producing the antibody; an immunological assay method using the antibody; and a method of estimating any hypercoagulable state of test specimen through assay of soluble fibrin contained in the test specimen by the immunological assay method. The use of this monoclonal antibody would realize specific detection of any soluble fibrin reflecting only an initial hypercoagulability and not being acted on by plasmin.
La présente invention concerne un anticorps monoclonal dirigé contre la fibrine soluble qui est capable de reconnaître spécifiquement un site de changement structural nouvellement apparu dans la région C-terminale d'une chaîne A.alpha. de fibrine soluble formée par digestion du fibrinogène par la thrombine ; un hybridome capable de produire l'anticorps ; un procédé d'essai immunologique utilisant l'anticorps ; et un procédé d'estimation de tout état hypercoagulable d'un spécimen de test par le procédé d'essai immunologique. L'utilisation de cet anticorps monoclonal réaliserait la détection spécifique de toute fibrine soluble reflétant seulement une hypercoagulabilité initiale et n'étant pas provoquée par la plasmine.
Ebinuma Hiroyuki
Matsuo Masanao
Miyazaki Osamu
Suzuki Akiko
Tanaka Kyoko
Daiichi Pure Chemicals Co. Ltd.
Gowling Lafleur Henderson Llp
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