Anti-human tenascin monoclonal antibody

Details Anti-human tenascin monoclonal antibody Anti-human tenascin monoclonal antibody

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12N 5/12 (2006.01) C12N 5/20 (2006.01) C12P 21/08 (2006.01) G01N 33/543 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2475395

A novel anti-human tenascin ST2146 monoclonal antibody is described endowed with high affinity with the native antigen and high tumor selectivity. The cST2146 hybridoma is stably producing the antibody in high density culture conditions and is suitable for the industrial development of ST2146-based products. ST2146 exhibits properties exploitable for both therapeutic and diagnostic applications.

La présente invention a trait à un nouvel anticorps monoclonal anti-humain de la tenascine ST2146 présentant une affinité élevée avec l'antigène natif et une sélectivité élevée des tumeurs. L'hybridome cST2146 produit de manière stable l'anticorps dans des conditions de culture à densité élevée et est apte au développement industriel de produits à base de ST2146. Le ST2146 présente des propriétés exploitables à la fois pour des applications thérapeutiques et diagnostiques.

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