C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/18 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2243302
The present invention provides a monoclonal antibody which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and a monoclonal antibody which inhibits binding of human VEGF to human VEGF receptor Flt-1. It also provides a means for the diagnosis or treatment of diseases in which their morbid states progress by abnormal angiogenesis, such as proliferation or metastasis of solid tumors, arthritis in rheumatoid arthritis, diabetic retinopathy, retinopathy of prematurity, psoriasis, and the like.
La présente invention concerne un anticorps monoclonal qui réagit immunologiquement avec un récepteur F1t-1 VEGF humain, des cellules comportant le récepteur F1t-1 VEGF humain exprimé et analogues. Ledit anticorps monoclonal présente une activité inhibitrice à l'encontre de la liaison d'un VEGF humain avec un récepteur F1t-1 VEGF. La présente invention concerne également l'utilisation de l'anticorps monoclonal pour le diagnostic et le traitement de maladies dans lesquelles la condition pathologique progresse par vascularisation anormale à savoir la propagation et les métastases des tumeurs solides, l'arthrite dans les rhumatismes articulaires chroniques, la rétinopathie diabétique, la rétinopathie de prématurité et le psoriasis.
Hanai Nobuo
Ito Mikito
Shibuya Masabumi
Shitara Kenya
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Kyowa Hakko Kirin Co. Ltd.
Kyowa Hakko Kogyo Co. Ltd.
LandOfFree
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