C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 205/08 (2006.01) A61K 31/397 (2006.01) A61P 3/06 (2006.01)
Patent
CA 2624481
This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
La présente invention concerne des inhibiteurs d'absorption de cholestérol de Formule I : ainsi que les sels et esters de qualité pharmaceutique desdits composés. Les composés peuvent être employés pour diminuer les teneurs plasmatiques en cholestérol, en particulier en cholestérol LDL, et pour le traitement prophylactique et thérapeutique de l'athérosclérose et d'événements liés aux maladies athérosclérotiques.
Devita Robert J.
Lin Peter
Morriello Gregori J.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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