C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2685465
The present invention provides anti-human ICOS antibodies with increased effector function. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human ICOS antigen and that may mediate ADCC, CDC, and/or antibody-dependent phagocytosis (opsonisation) for the treatment and prevention of T cell-mediated diseases and disorders, such as, but not limited to, chronic infection, autoimmune disease or disorder, inflammatory disease or disorder, graft-versus-host disease (GVHD), transplant rejection, and T cell proliferative disorder.
La présente invention concerne des anticorps anti-ICOS humains avec une fonction effectrice accrue. L'invention concerne également des compositions pharmaceutiques, des compositions immunothérapeutiques, et des procédés mettant en AEuvre des anticorps thérapeutiques se liant à l'antigène ICOS humain et pouvant médier la phagocytose (opsonisation) ADCC, CDC, et/ou dépendant d'anticorps pour le traitement et la prévention de maladies et de troubles médiés par les lymphocytes T, tels que, entre autres, une infection chronique, un maladie ou un trouble auto-immun(e), une maladie ou un trouble inflammatoire, une réaction de greffe contre hôte, un rejet du transplant, et un trouble proliférant de lymphocytes T.
Bowen Michael
Carlesso Gianluca
Coyle Anthony
Jallal Bahija
Yao Yihong
Medimmune Llc
Smart & Biggar
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