C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/42 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2481829
The present invention provides molecules, preferably designed immunoglubulins, suitable for use as an anti-idiotype vaccine to CEA positive tumours. The molecules induce both an MHC class I and MHC class II mediated immune response to the CEA bearing tumour cells for an efficient and sustained host anti- tumour response. The present invention provides modified versions of anti- idiotype anti-CEA antibodies, preferably mouse antibody 708, with improved vaccination properties. The modifications are related to the introduction of sequences tracts deriving from e.g. CEA, CD55 antigen and CEA cancer-specific MHC epitopes into the variable regions of said antibody molecules.
L'invention concerne des molécules, de préférence, des immunoglobulines particulières s'étant révélées appropriées pour l'utilisation comme vaccin anti-idiotype pour des tumeurs CEA positives. Les molécules induisent une réponse immune, exercée à la fois par la classe I MHC et la classe II MHC, aux cellules tumorales porteuses de CEA pour une réponse antitumorale hôte efficace et soutenue. L'invention concerne des versions modifiées d'anticorps anti-CEA idiotypes, de préférence d'anticorps 708 de la souris, à propriétés de vaccination améliorées. Les modifications sont liées à l'introduction de zones séquentielles provenant, par exemple, de CEA, antigène CD55 et d'épitopes MHC spécifiques de cancer CEA, dans les régions variables desdites molécules d'anticorps.
Carr Francis J.
Carter Graham
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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