Anti-idiotypic antibodies against antibodies which inhibit...

Details Anti-idiotypic antibodies against antibodies which inhibit... Anti-idiotypic antibodies against antibodies which inhibit...

C - Chemistry, Metallurgy

07

K

C07K 16/42 (2006.01) A61K 39/395 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2363991

Antibodies and antibody fragments which are anti-idiotypic to an antibody that interferes with the binding of the C~3 region of IgE to its high affinity receptor (mimobodies), particularly, which are anti- idiotypic to BSW17 (BSW17-mimobodies) are described, as well as their use as pharmaceuticals, especially vaccines, in the treatment of IgE- mediated diseases.

Cette invention, qui a trait à des anticorps et à des fragments d'anticorps anti-idiotypiques d'un anticorps interférant avec la fixation de la région C.epsilon.3 de l'IgE à son récepteur à haute affinité (mimocorps), concerne notamment des anticorps et des fragments d'anticorps anti-idiotypiques de BSW17 (mimocorps-BSW17). Elle porte également sur leur utilisation en tant que substances pharmaceutiques, notamment comme vaccins, dans le traitement de maladies liées à l'IgE.

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