C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/42 (2006.01) A61K 39/395 (2006.01) A61P 31/18 (2006.01) C12N 5/20 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2473163
The invention relates to Ab2-type anti-idiotypic antibodies and fragments thereof which mimic HIV-1 epitopes that are otherwise cryptic to the immune system and which antibodies or fragments thereof are directed against potently neutralizing anti-HIV-1 antibodies. The invention further relates to a hybridoma cell line 3H6 expressing the anti-idiotypic antibody and to pharmaceutical compositions containing said antibody or fragment thereof. The invention also relates to HIV-1 neutralizing Ab3-type antibodies elicited upon administration of a said Ab2-type anti-idiotypic antibody or fragment thereof and to pharmaceutical compositions containing them. The invention also relates to the use of the present antibodies or fragments thereof as screening tools or as diagnostic or therapeutic agents.
La présente invention concerne des anticorps anti-idiotypiques de type Ab2 et des fragments de ceux-ci dont les épitopes VIH-1 mimétiques qui sont autrement cryptiques pour le système immunitaire. Ces anticorps ou leurs fragments sont dirigés contre des anticorps anti-VIH-1 potentiellement neutralisants. La présente invention concerne également une lignée cellulaire hybridome 3H6 exprimant l'anticorps anti-idiotypique, et des compositions pharmaceutiques contenant cet anticorps ou un fragment de celui-ci. L'invention concerne également des anticorps de type Ab3 neutralisant le VIH-1 qui sont déclenchés à l'administration d'un anticorps anti-idiotypique de type Ab-2 ou d'un fragment de celui-ci, et des compositions pharmaceutiques les contenant. L'invention concerne l'utilisation de ces anticorps ou de leurs fragments en tant qu'outils de criblage ou en tant qu'agents thérapeutiques ou diagnostiques.
Katinger Hermann
Kunert Renate
Stiegler Gabriela
Weik Robert
Gowling Lafleur Henderson Llp
Polymun Scientific Immunbiologische Forschung Gmbh
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