Anti-idiotypic antibody which neutralizes the inhibitory...

Details Anti-idiotypic antibody which neutralizes the inhibitory... Anti-idiotypic antibody which neutralizes the inhibitory...

C - Chemistry, Metallurgy

07

K

C07K 16/42 (2006.01) A61K 39/395 (2006.01) A61P 7/04 (2006.01) C12N 5/12 (2006.01) C12N 15/13 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2643565

The present invention relates to an anti-idiotypic monoclonal antibody directed against a factor VIII-inhibiting antibody which binds to the C1 domain of factor VIII, and also to a cell line which produces this anti-idiotypic monoclonal antibody, to the use of this anti-idiotypic monoclonal antibody as a medicament, and more particularly to its use for the manufacture of a medicament for use in the treatment of haemophilia A.

La présente invention se rapporte à un anticorps monoclonal anti-idiotypique dirigé contre un anticorps inhibiteur du facteur VIII se liant au domaine C1 du facteur VIII, ainsi qu'à une lignée cellulaire produisant cet anticorps monoclonal anti-idiotypique, à l'utilisation de cet anticorps monoclonal anti-idiotypique comme médicament, et plus particulièrement à son utilisation pour la fabrication d'un médicament destiné au traitement de l'hémophilie A.

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